Ergotamine derivatives: Because of the theoretical probability of ergotism, the brand new concurrent the means to access azithromycin having ergot types isn’t required (come across section 4.4).
Whether or not neutropenia has been of usage of rifabutin, a beneficial causal link to combination having azithromycin hasn’t been built (find Area cuatro
Alerting is recommended in the co-administration of them medicines which have Azithromycin of the known increasing aftereffect of such medication when made use of while doing so on the macrolid antibiotic erythromycin.
Co-management of atorvastatin (10 milligrams each and every day) and you may azithromycin (five hundred milligrams every single day) didn’t change the plasma density of atorvastatin (based on a beneficial HMG CoA-reductase inhibition assay). not, post-income cases of rhabdomyolysis when you look at the patients researching azithromycin with statins possess been said.
In the an excellent pharmacokinetic communication study inside the suit volunteers, zero significant effect was seen toward plasma levels of carbamazepine otherwise the active metabolite when you look at the people researching concomitant azithromycin.
In the event a beneficial causal relationship hasn’t been mainly based, consideration should be made available to the newest frequency out-of keeping track of prothrombin date whenever azithromycin can be used in customers researching coumarin-form of dental anticoagulants
Cisapride are metabolized on liver from the chemical CYP 3A4. Because macrolides inhibit so it enzyme, concomitant government out-of cisapride may cause the increase out-of QT interval prolongation, ventricular arrhythmias and you will torsades de pointes.
Within the a great pharmacokinetic research investigating the consequences of 1 dose of cimetidine, given 2 hours in advance of azithromycin, with the pharmacokinetics regarding azithromycin, no alteration regarding azithromycin pharmacokinetics try viewed.
Within the an effective pharmacokinetic telecommunications investigation, azithromycin failed to change the anticoagulant aftereffect of an individual 15 mg dose of warfarin administered to healthy volunteers. There were account acquired in the article-purchases age of potentiated anticoagulation subsequent to co-government out-of azithromycin and coumarin-type of dental anticoagulants.
In a pharmacokinetic study with healthy volunteers that were administered a 500 mg/day oral dose of azithromycin for caribbeancupid PЕ™ihlГЎsit se 3 days and were then administered a single 10 mg/kg oral dose of cyclosporin, the resulting cyclosporin Cmaximum and AUC0-5 were found to be significantly elevated. Consequently, caution should be exercised before considering concurrent administration of these drugs. If co-administration of these drugs is necessary, cyclosporin levels should be monitored and the dose adjusted accordingly.
Co-government of a good 600 milligrams solitary dosage off azithromycin and 400 milligrams efavirenz every single day to own 1 week didn’t produce any clinically significant pharmacokinetic connections.
Co-administration of a single dose of 1200 mg azithromycin did not alter the pharmacokinetics of a single dose of 800 mg fluconazole. Total exposure and half-life of azithromycin were unchanged by the co-administration of fluconazole, however, a clinically insignificant decrease in Cmax (18%) of azithromycin was observed.
Co-management of a single dosage out-of 1200 milligrams azithromycin didn’t come with statistically extreme influence on the pharmacokinetics away from indinavir given while the 800 milligrams three times everyday for 5 weeks.
Into the healthy volunteers, co-administration of azithromycin five hundred milligrams/time to own three days failed to end up in medically tall changes in the latest pharmacokinetics and you will pharmacodynamics of just one fifteen mg serving of midazolam.
Co-government off azithromycin (1200 mg) and you can nelfinavir on steady-state (750 mg 3 times each and every day) resulted in enhanced azithromycin levels. No clinically high adverse effects was in fact seen no dose changes will become necessary.
In normal healthy male volunteers, there was no evidence of an effect of azithromycin (500 mg daily for 3 days) on the AUC and Cmax of sildenafil or its major circulating metabolite.
Pharmacokinetic studies have claimed no proof of a communicating anywhere between azithromycin and you may terfenadine. There were rare circumstances reported in which the chances of such as for example a communication could not become totally excluded; however there is no particular evidence you to definitely for example a relationships had taken place.